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This randomized prospective study compared two different therapeutic regimens, demonstrating that co-treatment with progestin is more accepted by the patients that co-treatment with gonadotropin-releasing hormone analogue.

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Of the 4246 events diagnosed among non-users of hormonal contraception or among users of products included in this study, 2847 (67.

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During the peri-menopausal and post-menopausal periods, estrogen depravation contributes to increasing levels of low-density lipoprotein (LDL) cholesterol and triglycerides (TGs) and decreasing levels of high-density lipoprotein (HDL) cholesterol ().

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Conclusions Relatively short-term combined estrogen plus progestin use increases incident breast cancers, which are diagnosed at a more advanced stage compared with placebo use, and also substantially increases the percentage of women with abnormal mammograms.

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Bias and lack of adjustment for confounders at the level of the individual studies cannot be corrected in the meta-analysis, so the validity of these results is dependent on quality of the primary observational data.

As this strong association with estrogen-only hormone therapy has also been seen with endometrial cancer, many studies, including 48 randomized trials, have examined the effect of combined estrogen and progestin postmenopausal hormone therapy on the development of endometrial pathology ().

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